Please read Dr. An’s article in the American Journal of Respiratory and Critical Care Medicine titled, “Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease.“
Gastroesophageal reflux disease (GERD), a condition caused by persistent regurgitation of gastric contents leading to the sequelae of esophageal and/or extraesophageal complications, is highly prevalent and occurs in ∼75% of patients with asthma. The frequent coexistence of traits, or GERD comorbidity in patients with asthma, may underlie common genetic etiology and/or pathogenic mechanisms shared between the two diseases. Of note, microaspiration of endogenous acids can reduce the pH of the airways and, via either reflex mechanisms or direct effects on the airways, has been proposed to contribute to the pathophysiology of obstructive lung diseases. To read the full article.
Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease. Ahn K, Penn RB, Rattan S, Panettieri RA Jr, Voight BF, An SS. Am J Respir Crit Care Med. 2023 Jan 15;207(2):130-137. PMID: 36214830 PMCID: PMC9893317 DOI: 10.1164/rccm.202205-0951OC