Please read Dr. Martin’s article in the JAMA Network Open titled, “Characteristics, Outcomes, and Severity Risk Factors Associated With SARS-CoV-2 Infection Among Children in the US National COVID Cohort Collaborative.“
As of January 2022, SARS-CoV-2 had infected more than 290 million people and caused more than 5.4 million deaths worldwide. The associated infection, COVID-19, is characterized by pneumonia, hypoxemic respiratory failure, cardiac and kidney dysfunction, and substantial mortality and morbidity. Although children often experience milder illness, SARS-CoV-2 can cause severe pediatric disease via both acute COVID-19 and multisystem inflammatory syndrome in children (MIS-C). MIS-C is a hyperinflammatory, postinfectious complication of SARS-CoV-2. Characterized by cardiovascular, respiratory, neurologic, gastrointestinal, and mucocutaneous manifestations and organ dysfunction, more than 5900 cases of MIS-C have been reported to the US Centers for Disease Control and Prevention, with more than half of the patients requiring intensive care unit admission and greater than one-third experiencing shock. To read the full article.
Characteristics, Outcomes, and Severity Risk Factors Associated With SARS-CoV-2 Infection Among Children in the US National COVID Cohort Collaborative. Martin B, DeWitt PE, Russell S, Anand A, Bradwell KR, Bremer C, Gabriel D, Girvin AT, Hajagos JG, McMurry JA, Neumann AJ, Pfaff ER, Walden A, Wooldridge JT, Yoo YJ, Saltz J, Gersing KR, Chute CG, Haendel MA, Moffitt R, Bennett TD. JAMA Netw Open. 2022 Feb 1;5(2):e2143151. PMID: 35133437 PMCID: PMC8826172 DOI: 1001/jamanetworkopen.2021.43151